1tce

Solution NMR

SOLUTION NMR STRUCTURE OF THE SHC SH2 DOMAIN COMPLEXED WITH A TYROSINE-PHOSPHORYLATED PEPTIDE FROM THE T-CELL RECEPTOR, MINIMIZED AVERAGE STRUCTURE

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-149096 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
SHC-transforming protein 1 Chain: A
Molecule details ›
Chain: A
Length: 107 amino acids
Theoretical weight: 12.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P29353 (Residues: 480-583; Coverage: 18%)
Gene names: SHC, SHC1, SHCA
Sequence domains: SH2 domain
Structure domains: SH2 domain
T-cell surface glycoprotein CD3 zeta chain Chain: B
Molecule details ›
Chain: B
Length: 14 amino acids
Theoretical weight: 1.53 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P20963 (Residues: 137-150; Coverage: 10%)
Gene names: CD247, CD3Z, T3Z, TCRZ
Sequence domains: Immunoreceptor tyrosine-based activation motif

Ligands and Environments

No bound ligands
1 modified residue:

Experiments and Validation Details

Entry percentile scores
Expression systems:
  • Escherichia coli
  • Not provided