PDBe 1sm3

X-ray diffraction
1.95Å resolution

CRYSTAL STRUCTURE OF THE TUMOR SPECIFIC ANTIBODY SM3 COMPLEX WITH ITS PEPTIDE EPITOPE

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig lambda-1 chain V region Chain: L
Molecule details ›
Chain: L
Length: 215 amino acids
Theoretical weight: 23.15 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P01723 (Residues: 23-117; Coverage: 98%)
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins
Ig heavy chain V-III region J606 Chain: H
Molecule details ›
Chain: H
Length: 218 amino acids
Theoretical weight: 23.46 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P01801 (Residues: 1-58, 60-100, 101-101, 102-115; Coverage: 99%)
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins
Mucin-1 subunit alpha Chain: P
Molecule details ›
Chain: P
Length: 13 amino acids
Theoretical weight: 1.26 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P15941 (Residues: 919-931; Coverage: 1%)
Gene names: MUC1, PUM

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P21
Unit cell:
a: 42.2Å b: 83.73Å c: 67.24Å
α: 90° β: 93.3° γ: 90°
R-values:
R R work R free
0.213 0.213 0.283
Expression system: Not provided