PDBe 1shh

X-ray diffraction
1.55Å resolution

Slow form of Thrombin Bound with PPACK

Released:
Source organism: Homo sapiens
Primary publication:
Molecular dissection of Na+ binding to thrombin.
J. Biol. Chem. 279 31842-53 (2004)
PMID: 15152000

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Thrombin light chain Chains: A, D
Molecule details ›
Chains: A, D
Length: 36 amino acids
Theoretical weight: 4.1 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P00734 (Residues: 328-363; Coverage: 6%)
Gene name: F2
Thrombin heavy chain Chains: B, E
Molecule details ›
Chains: B, E
Length: 259 amino acids
Theoretical weight: 29.69 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P00734 (Residues: 364-622; Coverage: 43%)
Gene name: F2
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: P212121
Unit cell:
a: 61.34Å b: 68.2Å c: 162.93Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.196 0.195 0.216
Expression system: Cricetulus griseus