PDBe 1sg1

X-ray diffraction
2.4Å resolution

Crystal Structure of the Receptor-Ligand Complex between Nerve Growth Factor and the Common Neurotrophin Receptor p75

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Beta-nerve growth factor Chains: A, B
Molecule details ›
Chains: A, B
Length: 120 amino acids
Theoretical weight: 13.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01138 (Residues: 122-241; Coverage: 54%)
Gene names: NGF, NGFB
Sequence domains: Nerve growth factor family
Structure domains: Cystine-knot cytokines
Tumor necrosis factor receptor superfamily member 16 Chain: X
Molecule details ›
Chain: X
Length: 161 amino acids
Theoretical weight: 17.26 KDa
Source organism: Rattus norvegicus
Expression system: unidentified baculovirus
UniProt:
  • Canonical: P07174 (Residues: 30-190; Coverage: 41%)
Gene names: Ngfr, Tnfrsf16
Sequence domains: TNFR/NGFR cysteine-rich region
Structure domains: Tumor Necrosis Factor Receptor, subunit A, domain 2

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P212121
Unit cell:
a: 49.692Å b: 91.796Å c: 92.01Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.245 0.243 0.269
Expression systems:
  • Escherichia coli
  • unidentified baculovirus