PDBe 1s2h

Solution NMR

The Mad2 spindle checkpoint protein possesses two distinct natively folded states

Source organism: Homo sapiens
Primary publication:
The Mad2 spindle checkpoint protein has two distinct natively folded states.
Nat. Struct. Mol. Biol. 11 338-45 (2004)
PMID: 15024386

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Mitotic spindle assembly checkpoint protein MAD2A Chain: A
Molecule details ›
Chain: A
Length: 206 amino acids
Theoretical weight: 23.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt: Gene names: MAD2, MAD2L1
Sequence domains: HORMA domain
Structure domains: HORMA domain

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli