PDBe 1rlw

X-ray diffraction
2.4Å resolution

CALCIUM-PHOSPHOLIPID BINDING DOMAIN FROM CYTOSOLIC PHOSPHOLIPASE A2

Released:

Function and Biology Details

Reactions catalysed:
Phosphatidylcholine + H(2)O = 1-acylglycerophosphocholine + a carboxylate
2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytosolic phospholipase A2 Chain: A
Molecule details ›
Chain: A
Length: 126 amino acids
Theoretical weight: 14.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: NEW P47712 (Residues: 17-141; Coverage: 17%)
Gene names: CPLA2, PLA2G4, PLA2G4A
Sequence domains: C2 domain
Structure domains: C2 domain

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE BW7B
Spacegroup: P3121
Unit cell:
a: 79.41Å b: 79.41Å c: 70.67Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.227 0.227 0.273
Expression system: Escherichia coli