PDBe 1qwt

X-ray diffraction
2.1Å resolution

Auto-inhibitory interferon regulation factor-3 (IRF3) transactivation domain

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interferon regulatory factor 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 255 amino acids
Theoretical weight: 28.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: NEW Q14653 (Residues: 173-427; Coverage: 60%)
Gene name: IRF3
Sequence domains: Interferon-regulatory factor 3
Structure domains: Tumour Suppressor Smad4

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P4212
Unit cell:
a: 135.545Å b: 135.545Å c: 68.521Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.195 0.214
Expression system: Escherichia coli