PDBe 1qqg

X-ray diffraction
2.3Å resolution

CRYSTAL STRUCTURE OF THE PH-PTB TARGETING REGION OF IRS-1

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin receptor substrate 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 264 amino acids
Theoretical weight: 29.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35568 (Residues: 4-267; Coverage: 21%)
Gene name: IRS1
Sequence domains:
Structure domains: Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ELLIOTT GX-13
Spacegroup: P65
Unit cell:
a: 120.439Å b: 120.439Å c: 79.598Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.191 0.191 0.247
Expression system: Escherichia coli