PDBe 1qqd

X-ray diffraction
2.7Å resolution

CRYSTAL STRUCTURE OF HLA-CW4, A LIGAND FOR THE KIR2D NATURAL KILLER CELL INHIBITORY RECEPTOR

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, Cw-4 alpha chain Chain: A
Molecule details ›
Chain: A
Length: 273 amino acids
Theoretical weight: 31.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P30504 (Residues: 26-298; Coverage: 80%)
Gene names: HLA-C, HLAC
Sequence domains: Immunoglobulin C1-set domain
Structure domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 99 amino acids
Theoretical weight: 11.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 20-118; Coverage: 99%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins
HLA-CW4 SPECIFIC PEPTIDE Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 1.12 KDa

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P212121
Unit cell:
a: 54.96Å b: 77.49Å c: 108.59Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.223 0.275
Expression system: Escherichia coli