PDBe 1qki

X-ray diffraction
3Å resolution

X-RAY STRUCTURE OF HUMAN GLUCOSE 6-PHOSPHATE DEHYDROGENASE (VARIANT CANTON R459L) COMPLEXED WITH STRUCTURAL NADP+

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glucose-6-phosphate 1-dehydrogenase Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 514 amino acids
Theoretical weight: 59.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11413 (Residues: 2-515; Coverage: 100%)
Gene name: G6PD
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand NAP 8 x NAP
2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.6
Spacegroup: P212121
Unit cell:
a: 128.9Å b: 208.7Å c: 214.3Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.247 0.247 0.294
Expression system: Escherichia coli