PDBe 1qab

X-ray diffraction
3.2Å resolution

The structure of human retinol binding protein with its carrier protein transthyretin reveals interaction with the carboxy terminus of RBP

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transthyretin Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 127 amino acids
Theoretical weight: 13.78 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain
Retinol-binding protein 4 Chains: E, F
Molecule details ›
Chains: E, F
Length: 180 amino acids
Theoretical weight: 20.44 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02753 (Residues: 22-201; Coverage: 98%)
Gene names: PRO2222, RBP4
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P41212
Unit cell:
a: 140.23Å b: 140.23Å c: 124.08Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.278 0.278 0.403