PDBe 1q3l

X-ray diffraction
1.64Å resolution

Chromodomain Of HP1 Complexed With Histone H3 Tail Containing monomethyllysine 9.

Released:
Entry authors: Jacobs SA, Khorasanizadeh S

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Heterochromatin protein 1 Chain: A
Molecule details ›
Chain: A
Length: 69 amino acids
Theoretical weight: 8.59 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: NEW P05205 (Residues: 17-76; Coverage: 29%)
Gene names: CG8409, HP1, Su(var)205
Sequence domains: Chromo (CHRromatin Organisation MOdifier) domain
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Histone H3.1 Chain: P
Molecule details ›
Chain: P
Length: 16 amino acids
Theoretical weight: 1.74 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: NEW P68431 (Residues: 2-17; Coverage: 12%)
Gene names: H3FA, H3FB, H3FC, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL, HIST1H3A, HIST1H3B, HIST1H3C, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X25
Spacegroup: C2221
Unit cell:
a: 33.809Å b: 76.828Å c: 75.625Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.222 0.241
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided