› 1puo

X-ray diffraction
1.85Å resolution

Crystal structure of Fel d 1- the major cat allergen

Released:
DOI: 10.2210/pdb1puo/pdb
PDB entry 1puo coloured by chain, front view.
PDB entry 1puo coloured by chain, side view.
PDB entry 1puo coloured by chain, top view.
Source organism: Felis catus
Primary publication:
The crystal structure of the major cat allergen Fel d 1, a member of the secretoglobin family.
Kaiser L, Grönlund H, Sandalova T, Ljunggren HG, van Hage-Hamsten M, Achour A, Schneider G
J Biol Chem 278 37730-5 (2003)
PMID: 12851385

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151745 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Major allergen I polypeptide chain 1; Major allergen I polypeptide chain 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 170 amino acids
Theoretical weight: 19.07 KDa
Source organism: Felis catus
Expression system: Escherichia coli
UniProt:
  • Canonical: P30440 (Residues: 18-109; Coverage: 100%)
  • Canonical: P30438 (Residues: 23-92; Coverage: 100%)
Gene names: CH1, CH2
Sequence domains:
Structure domains: Histone Acetyltransferase; Chain A

Ligands and Environments

1 bound ligand:
Ligand MPD 4 x MPD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I711, ESRF BEAMLINE ID29
Spacegroup: P21
Unit cell:
a: 43.29Å b: 51.539Å c: 67.725Å
α: 90° β: 95.27° γ: 90°
R-values:
R R work R free
0.203 0.201 0.237
Expression system: Escherichia coli

Quick links

Citations

18 review citations

Nomenclature and structural biology of allergens.
Chapman et al. (2007)
17 more

9 mentions without citation

Relevant B cell epitopes in allergic disease.
Pomés A. (2010)
8 more