PDBe 1p8v

X-ray diffraction
2.6Å resolution

CRYSTAL STRUCTURE OF THE COMPLEX OF PLATELET RECEPTOR GPIB-ALPHA AND ALPHA-THROMBIN AT 2.6A

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Glycocalicin Chain: A
Molecule details ›
Chain: A
Length: 279 amino acids
Theoretical weight: 31.24 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P07359 (Residues: 17-294; Coverage: 44%)
Gene name: GP1BA
Sequence domains:
Structure domains: Ribonuclease Inhibitor
Thrombin light chain Chain: B
Molecule details ›
Chain: B
Length: 29 amino acids
Theoretical weight: 3.43 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00734 (Residues: 333-361; Coverage: 5%)
Gene name: F2
Thrombin heavy chain Chain: C
Molecule details ›
Chain: C
Length: 259 amino acids
Theoretical weight: 29.78 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00734 (Residues: 364-621; Coverage: 43%)
Gene name: F2
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

3 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P212121
Unit cell:
a: 47.095Å b: 111.77Å c: 176.251Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.207 0.207 0.238
Expression system: Cricetulus griseus