PDBe 1owt

Solution NMR

Structure of the Alzheimer's disease amyloid precursor protein copper binding domain


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
N-APP Chain: A
Molecule details ›
Chain: A
Length: 66 amino acids
Theoretical weight: 7.59 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
  • Canonical: P05067 (Residues: 124-189; Coverage: 9%)
Gene names: A4, AD1, APP
Sequence domains: Copper-binding of amyloid precursor, CuBD
Structure domains: Amyloidogenic glycoprotein, copper-binding domain

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry and simulated annealing
Expression system: Komagataella pastoris