PDBe 1op9

X-ray diffraction
1.86Å resolution

Complex of human lysozyme with camelid VHH HL6 antibody fragment


Function and Biology Details

Reaction catalysed:
Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
HL6 camel VHH fragment Chain: A
Molecule details ›
Chain: A
Length: 121 amino acids
Theoretical weight: 13.04 KDa
Source organism: Camelus dromedarius
Expression system: Escherichia coli
Structure domains: Immunoglobulins
Lysozyme C Chain: B
Molecule details ›
Chain: B
Length: 130 amino acids
Theoretical weight: 14.72 KDa
Source organism: Homo sapiens
Expression system: Aspergillus niger
  • Canonical: P61626 (Residues: 19-148; Coverage: 100%)
Gene names: LYZ, LZM
Sequence domains: C-type lysozyme/alpha-lactalbumin family
Structure domains: Lysozyme

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P21
Unit cell:
a: 39.611Å b: 48.226Å c: 66.605Å
α: 90° β: 98.98° γ: 90°
R R work R free
0.197 0.196 0.238
Expression systems:
  • Escherichia coli
  • Aspergillus niger