PDBe 1o7a

X-ray diffraction
2.25Å resolution

Human beta-Hexosaminidase B

Released:

Function and Biology Details

Reaction catalysed:
Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-hexosaminidase subunit beta Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 515 amino acids
Theoretical weight: 58.93 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: NEW P07686 (Residues: 42-556; Coverage: 100%)
Gene names: HCC7, HEXB
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P3121
Unit cell:
a: 163.931Å b: 163.931Å c: 244.717Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.196 0.196 0.236
Expression system: Spodoptera frugiperda