PDBe 1o77

X-ray diffraction
3.2Å resolution

CRYSTAL STRUCTURE OF THE C713S MUTANT OF THE TIR DOMAIN OF HUMAN TLR2

Released:
Source organism: Homo sapiens
Primary publication:
An extensively associated dimer in the structure of the C713S mutant of the TIR domain of human TLR2.
Biochem. Biophys. Res. Commun. 299 216-21 (2002)
PMID: 12437972

Function and Biology Details

Structure analysis Details

Assemblies composition:
homo tetramer
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Toll-like receptor 2 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 146 amino acids
Theoretical weight: 17.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O60603 (Residues: 639-784; Coverage: 19%)
Gene names: TIL4, TLR2
Sequence domains: TIR domain
Structure domains: Toll/interleukin-1 receptor homology (TIR) domain

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 32-ID
Spacegroup: P6522
Unit cell:
a: 112.3Å b: 112.3Å c: 362.8Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.249 0.249 0.315
Expression system: Escherichia coli BL21(DE3)