PDBe 1o6p

X-ray diffraction
2.8Å resolution

Importin Beta bound to a GLFG Nucleoporin peptide

Primary publication:
GLFG and FxFG nucleoporins bind to overlapping sites on importin-beta.
J. Biol. Chem. 277 50597-606 (2002)
PMID: 12372823

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Importin subunit beta-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 442 amino acids
Theoretical weight: 49.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q14974 (Residues: 1-442; Coverage: 51%)
  • Best match: Q14974-2 (Residues: 1-297)
Gene names: KPNB1, NTF97
Sequence domains:
Structure domains: Leucine-rich Repeat Variant
Nucleoporin NUP116/NSP116 Chains: C, D, E, F
Molecule details ›
Chains: C, D, E, F
Length: 9 amino acids
Theoretical weight: 868 Da
Source organism: synthetic construct
Expression system: Not provided
  • Canonical: Q02630 (Residues: 602-609; Coverage: 1%)
Gene names: NSP116, NUP116, YM9532.12C, YMR047C

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.1
Spacegroup: P21
Unit cell:
a: 125.82Å b: 67.03Å c: 129.26Å
α: 90° β: 98.99° γ: 90°
R R work R free
0.238 0.238 0.267
Expression systems:
  • Escherichia coli
  • Not provided