PDBe 1nzq

X-ray diffraction
2.18Å resolution

D-Phe-Pro-Arg-Type Thrombin Inhibitor

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Thrombin light chain Chain: L
Molecule details ›
Chain: L
Length: 36 amino acids
Theoretical weight: 4.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00734 (Residues: 328-363; Coverage: 6%)
Gene name: F2
Thrombin heavy chain Chain: H
Molecule details ›
Chain: H
Length: 259 amino acids
Theoretical weight: 29.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00734 (Residues: 364-622; Coverage: 43%)
Gene name: F2
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Decapeptide Hirudin Analogue Chain: D
Molecule details ›
Chain: D
Length: 11 amino acids
Theoretical weight: 1.51 KDa

Ligands and Environments

1 bound ligand:

3 modified residues:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: C2
Unit cell:
a: 71.11Å b: 71.96Å c: 73.16Å
α: 90° β: 100.82° γ: 90°
R-values:
R R work R free
0.197 0.197 0.242
Expression system: Escherichia coli