PDBe 1nun

X-ray diffraction
2.9Å resolution

Crystal Structure Analysis of the FGF10-FGFR2b Complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fibroblast growth factor 10 Chain: A
Molecule details ›
Chain: A
Length: 145 amino acids
Theoretical weight: 16.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O15520 (Residues: 64-208; Coverage: 85%)
Gene name: FGF10
Sequence domains: Fibroblast growth factor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)
Fibroblast growth factor receptor 2 Chain: B
Molecule details ›
Chain: B
Length: 230 amino acids
Theoretical weight: 25.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P21802 (Residues: 140-361, 362-368; Coverage: 28%)
  • Best match: P21802-22 (Residues: 51-280)
Gene names: BEK, FGFR2, KGFR, KSAM
Sequence domains: Immunoglobulin I-set domain
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P6422
Unit cell:
a: 113.93Å b: 113.93Å c: 164.852Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.234 0.239 0.288
Expression system: Escherichia coli BL21