PDBe 1nro

X-ray diffraction
3.1Å resolution

CRYSTALLOGRAPHIC STRUCTURES OF THROMBIN COMPLEXED WITH THROMBIN RECEPTOR PEPTIDES: EXISTENCE OF EXPECTED AND NOVEL BINDING MODES

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Thrombin light chain Chain: L
Molecule details ›
Chain: L
Length: 36 amino acids
Theoretical weight: 4.1 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P00734 (Residues: 328-363; Coverage: 6%)
Gene name: F2
Thrombin heavy chain Chain: H
Molecule details ›
Chain: H
Length: 259 amino acids
Theoretical weight: 29.78 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P00734 (Residues: 364-622; Coverage: 43%)
Gene name: F2
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Proteinase-activated receptor 1 Chain: R
Molecule details ›
Chain: R
Length: 27 amino acids
Theoretical weight: 3.38 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P25116 (Residues: 38-64; Coverage: 7%)
Gene names: CF2R, F2R, PAR1, TR

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 128.1Å b: 51.8Å c: 62.9Å
α: 90° β: 101° γ: 90°
R-values:
R R work R free
0.171 not available not available
Expression system: Not provided