PDBe 1nq7

X-ray diffraction
1.5Å resolution

Characterization of ligands for the orphan nuclear receptor RORbeta

Released:

Function and Biology Details

Reaction catalysed:
Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N(6)-acetyl-L-lysine. 
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Nuclear receptor ROR-beta Chain: A
Molecule details ›
Chain: A
Length: 244 amino acids
Theoretical weight: 28.17 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P45446 (Residues: 219-462; Coverage: 52%)
Gene names: Nr1f2, Rorb, Rzrb
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 1 Chain: B
Molecule details ›
Chain: B
Length: 10 amino acids
Theoretical weight: 1.29 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15788 (Residues: 687-696; Coverage: 1%)
Gene names: BHLHE74, NCOA1, SRC1

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 52.823Å b: 58.343Å c: 105.668Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.201 0.22
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided