PDBe 1nou

X-ray diffraction
2.4Å resolution

Native human lysosomal beta-hexosaminidase isoform B

Released:

Function and Biology Details

Reaction catalysed:
Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-hexosaminidase subunit beta Chains: A, B
Molecule details ›
Chains: A, B
Length: 507 amino acids
Theoretical weight: 58.18 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: NEW P07686 (Residues: 50-556; Coverage: 99%)
Gene names: HCC7, HEXB
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: P6122
Unit cell:
a: 112.465Å b: 112.465Å c: 397.867Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.203 0.201 0.231