PDBe 1nfb

X-ray diffraction
2.9Å resolution

Ternary complex of the human type II Inosine Monophosphate Dedhydrogenase with 6Cl-IMP and NAD

Source organism: Homo sapiens
Entry authors: Risal D, Strickler MD, Goldstein BM

Function and Biology Details

Reaction catalysed:
Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Inosine-5'-monophosphate dehydrogenase 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 514 amino acids
Theoretical weight: 55.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P12268 (Residues: 1-514; Coverage: 100%)
Gene names: IMPD2, IMPDH2
Sequence domains:
Structure domains: Aldolase class I

Ligands and Environments

Cofactor: Ligand NAD 2 x NAD
1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: I4
Unit cell:
a: 145.19Å b: 145.19Å c: 127.1Å
α: 90° β: 90° γ: 90°
R R work R free
0.291 0.229 0.274
Expression system: Escherichia coli BL21(DE3)