› 1nf7

X-ray diffraction
2.65Å resolution

Ternary complex of the human type II Inosine Monophosphate Dedhydrogenase with Ribavirin Monophosphate and C2-Mycophenolic Adenine Dinucleotide

Released:
DOI: 10.2210/pdb1nf7/pdb
PDB entry 1nf7 coloured by chain, front view.
PDB entry 1nf7 coloured by chain, side view.
PDB entry 1nf7 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Risal D, Strickler MD, Goldstein BM

Function and Biology Details

Reaction catalysed: 
Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146109 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inosine-5'-monophosphate dehydrogenase 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 514 amino acids
Theoretical weight: 55.87 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P12268 (Residues: 1-514; Coverage: 100%)
Gene names: IMPD2, IMPDH2
Sequence domains:
Structure domains: Aldolase class I

Ligands and Environments

4 bound ligands:
Ligand K 2 x K
Ligand RVP 2 x RVP
Ligand MYD 2 x MYD
Ligand UNK 11 x UNK
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: I4
Unit cell:
a: 146.58Å b: 146.58Å c: 128.92Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.296 0.238 0.277
Expression system: Escherichia coli BL21(DE3)

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