› 1mzn

X-ray diffraction
1.9Å resolution

CRYSTAL STRUCTURE at 1.9 ANGSTROEMS RESOLUTION OF THE HOMODIMER OF HUMAN RXR ALPHA LIGAND BINDING DOMAIN BOUND TO THE SYNTHETIC AGONIST COMPOUND BMS 649 AND A COACTIVATOR PEPTIDE

Released:
DOI: 10.2210/pdb1mzn/pdb
PDB entry 1mzn coloured by chain, front view.
PDB entry 1mzn coloured by chain, side view.
PDB entry 1mzn coloured by chain, top view.
Source organisms:
Primary publication:
Molecular recognition of agonist ligands by RXRs.
Egea PF, Mitschler A, Moras D
Mol Endocrinol 16 987-97 (2002)
PMID: 11981034

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148727 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Retinoic acid receptor RXR-alpha Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 240 amino acids
Theoretical weight: 26.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19793 (Residues: 223-462; Coverage: 52%)
Gene names: NR2B1, RXRA
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor
Nuclear receptor coactivator 2 Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 13 amino acids
Theoretical weight: 1.58 KDa
Source organism: synthetic construct
Expression system: Not provided
UniProt:
  • Canonical: Q15596 (Residues: 686-698; Coverage: 1%)
Gene names: BHLHE75, NCOA2, SRC2, TIF2

Ligands and Environments

1 bound ligand:
Ligand BM6 4 x BM6
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P1
Unit cell:
a: 47.119Å b: 64.694Å c: 94.784Å
α: 109.97° β: 92.87° γ: 89.99°
R-values:
R R work R free
0.232 0.195 0.232
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

13 review citations

Long-chain omega-3 fatty acids and the brain: a review of the independent and shared effects of EPA, DPA and DHA.
Dyall SC. (2015)
12 more

8 mentions without citation

The retinoid X receptors and their ligands.
Dawson et al. (2012)
7 more