PDBe 1mk2

X-ray diffraction
2.74Å resolution

SMAD3 SBD complex

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero tetramer
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Mothers against decapentaplegic homolog 3 Chain: A
Molecule details ›
Chain: A
Length: 206 amino acids
Theoretical weight: 23.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P84022 (Residues: 220-425; Coverage: 49%)
Gene names: MADH3, SMAD3
Sequence domains: MH2 domain
Structure domains: Tumour Suppressor Smad4
Zinc finger FYVE domain-containing protein 9 Chain: B
Molecule details ›
Chain: B
Length: 38 amino acids
Theoretical weight: 3.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O95405 (Residues: 773-810; Coverage: 3%)
Gene names: MADHIP, SARA, SMADIP, ZFYVE9

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P21212
Unit cell:
a: 49.995Å b: 71.716Å c: 86.886Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.227 0.227 0.271
Expression system: Escherichia coli