PDBe 1mh0

X-ray diffraction
2.8Å resolution

Crystal structure of the anticoagulant slow form of thrombin

Released:
Source organism: Homo sapiens
Primary publication:
Crystal structure of the anticoagulant slow form of thrombin.
J. Biol. Chem. 277 40177-80 (2002)
PMID: 12205081

Function and Biology Details

Reaction catalysed:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thrombin heavy chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 287 amino acids
Theoretical weight: 33.01 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P00734 (Residues: 334-620; Coverage: 48%)
Gene name: F2
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P212121
Unit cell:
a: 60.53Å b: 72.89Å c: 161.49Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.219 0.275
Expression system: Cricetulus griseus