PDBe 1meh

X-ray diffraction
1.95Å resolution

Inosine Monophosphate Dehydrogenase (IMPDH) From Tritrichomonas Foetus with IMP and MOA bound

Released:

Function and Biology Details

Reaction catalysed:
Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Inosine-5'-monophosphate dehydrogenase Chain: A
Molecule details ›
Chain: A
Length: 503 amino acids
Theoretical weight: 55.56 KDa
Source organism: Tritrichomonas suis
Expression system: Escherichia coli
UniProt:
  • Canonical: P50097 (Residues: 1-503; Coverage: 100%)
Gene name: IMPDH
Sequence domains:
Structure domains: Aldolase class I

Ligands and Environments

3 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: P432
Unit cell:
a: 153.48Å b: 153.48Å c: 153.48Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.243 0.243 0.272
Expression system: Escherichia coli