PDBe 1m7w

X-ray diffraction
2.8Å resolution

HNF4a ligand binding domain with bound fatty acid


Function and Biology Details

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo octamer
homo tetramer
Entry contents:
1 distinct polypeptide molecule
Hepatocyte nuclear factor 4-alpha Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 250 amino acids
Theoretical weight: 28.12 KDa
Source organism: Rattus rattus
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P22449 (Residues: 142-391; Coverage: 53%)
Gene names: Hnf-4, Hnf4, Hnf4a, Nr2a1, Tcf14
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: P41212
Unit cell:
a: 102.288Å b: 102.288Å c: 227.688Å
α: 90° β: 90° γ: 90°
R R work R free
0.237 0.237 0.282
Expression system: Escherichia coli BL21(DE3)