PDBe 1m76

X-ray diffraction
2.15Å resolution

Crystal Structure of the S137C Mutant of L-3-HYDROXYACYL-COA Dehydrogenase in Complex with NAD and Acetoacetyl-COA

Released:
Source organism: Homo sapiens
Entry authors: Barycki JJ, Banaszak LJ

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 302 amino acids
Theoretical weight: 32.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16836 (Residues: 13-314; Coverage: 96%)
Gene names: HAD, HADH, HADHSC, SCHAD
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand NAD 2 x NAD
1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 50.392Å b: 87.992Å c: 158.972Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.208 0.257
Expression system: Escherichia coli