PDBe 1m4u

X-ray diffraction
2.42Å resolution

Crystal structure of Bone Morphogenetic Protein-7 (BMP-7) in complex with the secreted antagonist Noggin

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Noggin Chain: A
Molecule details ›
Chain: A
Length: 206 amino acids
Theoretical weight: 23.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13253 (Residues: 28-232; Coverage: 100%)
Gene name: NOG
Structure domains:
Bone morphogenetic protein 7 Chain: L
Molecule details ›
Chain: L
Length: 139 amino acids
Theoretical weight: 15.7 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P18075 (Residues: 293-431; Coverage: 35%)
Gene names: BMP7, OP1
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P41212
Unit cell:
a: 99.834Å b: 99.834Å c: 150.327Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.242 0.241 0.273
Expression systems:
  • Escherichia coli
  • Cricetulus griseus