PDBe 1lv2

X-ray diffraction
2.7Å resolution

Hepatocyte Nuclear Factor 4 is a Transcription Factor that Constitutively Binds Fatty Acids


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Hepatocyte nuclear factor 4-gamma Chain: A
Molecule details ›
Chain: A
Length: 229 amino acids
Theoretical weight: 25.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q14541 (Residues: 103-328; Coverage: 55%)
Gene names: HNF4G, NR2A2
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: I4122
Unit cell:
a: 152.708Å b: 152.708Å c: 93.421Å
α: 90° β: 90° γ: 90°
R R work R free
0.247 0.245 0.264
Expression system: Escherichia coli