› 1lhw

X-ray diffraction
1.75Å resolution

CRYSTAL STRUCTURE OF THE N-TERMINAL LG-DOMAIN OF SHBG IN COMPLEX WITH 2-METHOXYESTRADIOL

Released:
DOI: 10.2210/pdb1lhw/pdb
PDB entry 1lhw coloured by chain, front view.
PDB entry 1lhw coloured by chain, side view.
PDB entry 1lhw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of human sex hormone-binding globulin in complex with 2-methoxyestradiol reveals the molecular basis for high affinity interactions with C-2 derivatives of estradiol.
Avvakumov GV, Grishkovskaya I, Muller YA, Hammond GL
J Biol Chem 277 45219-25 (2002)
PMID: 12228253

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137579 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sex hormone-binding globulin Chain: A
Molecule details ›
Chain: A
Length: 189 amino acids
Theoretical weight: 20.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04278 (Residues: 30-218; Coverage: 51%)
Gene name: SHBG
Sequence domains: Laminin G domain
Structure domains: Jelly Rolls

Ligands and Environments

3 bound ligands:
Ligand CA 1 x CA
Ligand ESM 1 x ESM
Ligand IPA 1 x IPA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE BW7B
Spacegroup: R32
Unit cell:
a: 103.92Å b: 103.92Å c: 84.46Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.21 0.21 0.238
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Diverse roles for sex hormone-binding globulin in reproduction.
Hammond GL. (2011)
4 more

1 mention without citation

Unleashing the power of meta-threading for evolution/structure-based function inference of proteins.
Brylinski M. (2013)