PDBe 1lb5

X-ray diffraction
2.4Å resolution

TRAF6-RANK Complex

Released:

Function and Biology Details

Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
TNF receptor-associated factor 6 Chain: A
Molecule details ›
Chain: A
Length: 160 amino acids
Theoretical weight: 18.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: NEW Q9Y4K3 (Residues: 347-504; Coverage: 30%)
Gene names: RNF85, TRAF6
Structure domains: Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2; Chain A
Tumor necrosis factor receptor superfamily member 11A Chain: B
Molecule details ›
Chain: B
Length: 8 amino acids
Theoretical weight: 1.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: NEW Q9Y6Q6 (Residues: 342-349; Coverage: 1%)
Gene names: RANK, TNFRSF11A

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P212121
Unit cell:
a: 37.99Å b: 44.991Å c: 106.535Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.213 0.213 0.242
Expression system: Escherichia coli