› 1l8r

X-ray diffraction
1.65Å resolution

Structure of the Retinal Determination Protein Dachshund Reveals a DNA-Binding Motif

Released:
DOI: 10.2210/pdb1l8r/pdb
PDB entry 1l8r coloured by chain, front view.
PDB entry 1l8r coloured by chain, side view.
PDB entry 1l8r coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the retinal determination protein Dachshund reveals a DNA binding motif.
Kim SS, Zhang RG, Braunstein SE, Joachimiak A, Cvekl A, Hegde RS
Structure 10 787-95 (2002)
PMID: 12057194

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193777 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dachshund homolog 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 101 amino acids
Theoretical weight: 11.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UI36 (Residues: 184-282; Coverage: 13%)
Gene names: DACH, DACH1
Sequence domains: SKI/SNO/DAC family
Structure domains: Ski

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 2 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P1
Unit cell:
a: 28.797Å b: 47.731Å c: 50.436Å
α: 60.75° β: 86.86° γ: 84.55°
R-values:
R R work R free
0.237 0.237 0.259
Expression system: Escherichia coli

Quick links

Citations

13 review citations

Induction and specification of cranial placodes.
Schlosser G. (2006)
12 more

8 mentions without citation

Dead-end elimination with perturbations (DEEPer): a provable protein design algorithm with continuous sidechain and backbone flexibility.
Hallen et al. (2013)
7 more