PDBe 1klu

X-ray diffraction
1.93Å resolution

Crystal structure of HLA-DR1/TPI(23-37) complexed with staphylococcal enterotoxin C3 variant 3B2 (SEC3-3B2)

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Enterotoxin type C-3 Chain: D
Molecule details ›
Chain: D
Length: 239 amino acids
Theoretical weight: 27.72 KDa
Source organism: Staphylococcus aureus
Expression system: Escherichia coli
UniProt:
  • Best match: P0A0L5 (Residues: 28-266)
Gene name: entC3
Triosephosphate isomerase Chain: C
Molecule details ›
Chain: C
Length: 15 amino acids
Theoretical weight: 1.47 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Best match: P60174 (Residues: 60-74)
Gene names: TPI, TPI1
HLA class II histocompatibility antigen, DR alpha chain Chain: A
Molecule details ›
Chain: A
Length: 179 amino acids
Theoretical weight: 20.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Best match: P01903 (Residues: 29-207)
Gene names: HLA-DRA, HLA-DRA1
HLA class II histocompatibility antigen, DRB1-1 beta chain Chain: B
Molecule details ›
Chain: B
Length: 190 amino acids
Theoretical weight: 22.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Best match: P04229 (Residues: 30-219)
Gene name: HLA-DRB1

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: R3
Unit cell:
a: 171.296Å b: 171.296Å c: 121.024Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.208 0.208 0.22
Expression systems:
  • Escherichia coli
  • Not provided