PDBe 1khu

X-ray diffraction
2.5Å resolution

Smad1 crystal structure reveals the details of BMP signaling pathway

Released:
Source organism: Homo sapiens

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mothers against decapentaplegic homolog 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 218 amino acids
Theoretical weight: 24.55 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q15797 (Residues: 248-465; Coverage: 47%)
Gene names: BSP1, MADH1, MADR1, SMAD1
Sequence domains: MH2 domain
Structure domains: Tumour Suppressor Smad4

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: R3
Unit cell:
a: 138.129Å b: 138.129Å c: 199.34Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.239 0.239 0.274