PDBe 1k6m

X-ray diffraction
2.4Å resolution

Crystal Structure of Human Liver 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase


Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 432 amino acids
Theoretical weight: 50.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P16118 (Residues: 40-471; Coverage: 92%)
  • Best match: P16118-2 (Residues: 9-406)
Gene names: F6PK, PFKFB1, PFRX
Sequence domains: Histidine phosphatase superfamily (branch 1)
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: C2
Unit cell:
a: 74.98Å b: 185.33Å c: 89.67Å
α: 90° β: 90.7° γ: 90°
R R work R free
0.217 0.217 0.257
Expression system: Escherichia coli BL21(DE3)