PDBe 1k05

X-ray diffraction
2.9Å resolution

Crystal structure of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
homo dimer
Entry contents:
1 distinct polypeptide molecule
Focal adhesion kinase 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 162 amino acids
Theoretical weight: 17.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: NEW Q05397 (Residues: 891-1052; Coverage: 15%)
Gene names: FAK, FAK1, PTK2
Sequence domains: Focal adhesion targeting region
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-3
Spacegroup: C2221
Unit cell:
a: 87.484Å b: 222.101Å c: 97.885Å
α: 90° β: 90° γ: 90°
R R work R free
0.245 0.245 0.285
Expression system: Escherichia coli