PDBe 1js3

X-ray diffraction
2.25Å resolution

Crystal structure of dopa decarboxylase in complex with the inhibitor carbidopa


Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Aromatic-L-amino-acid decarboxylase Chains: A, B
Molecule details ›
Chains: A, B
Length: 486 amino acids
Theoretical weight: 54 KDa
Source organism: Sus scrofa
Expression system: Escherichia coli
  • Canonical: P80041 (Residues: 1-486; Coverage: 100%)
Gene name: DDC
Sequence domains: Pyridoxal-dependent decarboxylase conserved domain
Structure domains:

Ligands and Environments

Cofactor: Ligand PLP 2 x PLP
2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LURE BEAMLINE D41A
Spacegroup: P62
Unit cell:
a: 154.36Å b: 154.36Å c: 86.78Å
α: 90° β: 90° γ: 120°
R R work R free
0.144 0.144 0.187
Expression system: Escherichia coli