PDBe 1jpp

X-ray diffraction
3.1Å resolution

The Structure of a beta-Catenin Binding Repeat from Adenomatous Polyposis Coli (APC) in Complex with beta-Catenin

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Catenin beta-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 538 amino acids
Theoretical weight: 58.84 KDa
Source organism: Mus musculus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q02248 (Residues: 134-671; Coverage: 69%)
Gene names: Catnb, Ctnnb1
Sequence domains: Armadillo/beta-catenin-like repeat
Structure domains: Leucine-rich Repeat Variant
Adenomatous polyposis coli protein Chains: C, D
Molecule details ›
Chains: C, D
Length: 15 amino acids
Theoretical weight: 1.79 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P25054 (Residues: 1021-1035; Coverage: 1%)
Gene names: APC, DP2.5

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL11-1
Spacegroup: P1
Unit cell:
a: 51.09Å b: 69.255Å c: 95.099Å
α: 68.7° β: 87.04° γ: 85.32°
R-values:
R R work R free
0.234 0.234 0.274
Expression systems:
  • Escherichia coli BL21
  • Not provided