PDBe 1ivo

X-ray diffraction
3.3Å resolution

Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains.


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Epidermal growth factor receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 622 amino acids
Theoretical weight: 68.78 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
  • Canonical: P00533 (Residues: 25-646; Coverage: 52%)
Gene names: EGFR, ERBB, ERBB1, HER1
Sequence domains:
Structure domains:
Epidermal growth factor Chains: C, D
Molecule details ›
Chains: C, D
Length: 53 amino acids
Theoretical weight: 6.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P01133 (Residues: 971-1023; Coverage: 5%)
Gene name: EGF
Sequence domains: EGF-like domain
Structure domains: Laminin

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P3121
Unit cell:
a: 220.164Å b: 220.164Å c: 113.121Å
α: 90° β: 90° γ: 120°
R R work R free
0.258 0.255 0.326
Expression systems:
  • Cricetulus griseus
  • Escherichia coli