PDBe 1itw

X-ray diffraction
1.95Å resolution

Crystal structure of the monomeric isocitrate dehydrogenase in complex with isocitrate and Mn


Function and Biology Details

Reaction catalysed:
(1a) isocitrate + NADP(+) = 2-oxalosuccinate + NADPH
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Isocitrate dehydrogenase [NADP] Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 741 amino acids
Theoretical weight: 80.51 KDa
Source organism: Azotobacter vinelandii
  • Canonical: P16100 (Residues: 1-741; Coverage: 100%)
Gene name: icd
Sequence domains: Monomeric isocitrate dehydrogenase

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P21
Unit cell:
a: 110.405Å b: 119.023Å c: 128.217Å
α: 90° β: 99.006° γ: 90°
R R work R free
0.193 0.193 0.228