PDBe 1hzf

X-ray diffraction
2.3Å resolution

C4ADG FRAGMENT OF HUMAN COMPLEMENT FACTOR C4A

Released:

Function and Biology Details

Reaction catalysed:
Selective cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg-|- bond in complement component C5 alpha-chain to form C5a and C5b.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C4d-A Chain: A
Molecule details ›
Chain: A
Length: 367 amino acids
Theoretical weight: 39.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: NEW P0C0L4 (Residues: 957-1323; Coverage: 21%)
Gene names: C4A, CO4, CPAMD2
Sequence domains: A-macroglobulin TED domain
Structure domains: Glycosyltransferase

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P212121
Unit cell:
a: 56.51Å b: 71.43Å c: 85.74Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.215 0.233
Expression system: Escherichia coli BL21