PDBe 1hxf

X-ray diffraction
2.1Å resolution

HUMAN THROMBIN COMPLEX WITH HIRUDIN VARIANT

Released:
Source organisms:
Primary publication:
The molecular environment of the Na+ binding site of thrombin.
Biophys. Chem. 63 185-200 (1997)
PMID: 9108691

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Thrombin light chain Chain: L
Molecule details ›
Chain: L
Length: 36 amino acids
Theoretical weight: 4.1 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00734 (Residues: 328-363; Coverage: 6%)
Gene name: F2
Thrombin heavy chain Chain: H
Molecule details ›
Chain: H
Length: 259 amino acids
Theoretical weight: 29.78 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00734 (Residues: 364-622; Coverage: 43%)
Gene name: F2
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Hirudin variant-1 Chain: I
Molecule details ›
Chain: I
Length: 10 amino acids
Theoretical weight: 1.21 KDa
Source organism: Hirudo medicinalis
Expression system: Not provided
UniProt:
  • Canonical: P01050 (Residues: 55-64; Coverage: 15%)

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 70.66Å b: 72.47Å c: 73.09Å
α: 90° β: 100.75° γ: 90°
R-values:
R R work R free
0.151 not available not available
Expression system: Not provided