PDBe 1he7

X-ray diffraction
2Å resolution

Human Nerve growth factor receptor TrkA

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
High affinity nerve growth factor receptor Chain: A
Molecule details ›
Chain: A
Length: 126 amino acids
Theoretical weight: 13.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P04629 (Residues: 285-413; Coverage: 16%)
  • Best match: P04629-4 (Residues: 193-315)
Gene names: MTC, NTRK1, TRK, TRKA
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X11
Spacegroup: P4322
Unit cell:
a: 50.854Å b: 50.854Å c: 107.808Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.237 0.237 0.276
Expression system: Escherichia coli BL21