PDBe 1he1

X-ray diffraction
2Å resolution

Crystal structure of the complex between the GAP domain of the Pseudomonas aeruginosa ExoS toxin and human Rac


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Exoenzyme S Chains: A, B
Molecule details ›
Chains: A, B
Length: 135 amino acids
Theoretical weight: 14.26 KDa
Source organism: Pseudomonas aeruginosa
Expression system: Escherichia coli
  • Canonical: Q51451 (Residues: 96-229; Coverage: 30%)
Gene name: exoS
Sequence domains: Yersinia virulence determinant (YopE)
Structure domains: Virulence factor YopE uncharacterised domain
Ras-related C3 botulinum toxin substrate 1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 176 amino acids
Theoretical weight: 19.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P63000 (Residues: 2-176; Coverage: 91%)
Gene names: MIG5, RAC1, TC25
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P212121
Unit cell:
a: 46.025Å b: 125.087Å c: 136.284Å
α: 90° β: 90° γ: 90°
R R work R free
0.175 0.175 0.224
Expression system: Escherichia coli