PDBe 1hdt

X-ray diffraction
2.6Å resolution

STRUCTURE OF A RETRO-BINDING PEPTIDE INHIBITOR COMPLEXED WITH HUMAN ALPHA-THROMBIN

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Thrombin light chain Chain: L
Molecule details ›
Chain: L
Length: 33 amino acids
Theoretical weight: 3.79 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00734 (Residues: 331-363; Coverage: 6%)
Gene name: F2
Thrombin heavy chain Chain: H
Molecule details ›
Chain: H
Length: 259 amino acids
Theoretical weight: 29.78 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00734 (Residues: 364-622; Coverage: 43%)
Gene name: F2
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Hirudin-3 Chain: P
Molecule details ›
Chain: P
Length: 12 amino acids
Theoretical weight: 1.55 KDa
Source organism: Hirudo medicinalis
Expression system: Not provided
UniProt:
  • Canonical: P28509 (Residues: 54-65; Coverage: 19%)

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21212
Unit cell:
a: 108.97Å b: 80.92Å c: 46.17Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.204 not available
Expression system: Not provided